The body responds to mechanical forces, such as work against gravity or resistance exercise, by remodeling bone and muscle tissue to accommodate new functional demands. These accommodations result in greater bone density and muscle strength. With age and in the absence of weight-bearing activity, bone loss (osteopenia or osteoporosis) and muscle loss (sarcopenia) ensue, which lead to injuries, reduced quality of life and large medical bills for many older individuals.
Current treatments directed at osteoporosis are predominantly based on inhibition of bone resorption by osteoclasts, rather than promotion of bone formation by osteoblasts, and are limited in the duration of their use. There are no currently available treatments for sarcopenia related to frailty.
The Vibe Approach
The musculoskeletal system must be able to respond to mechanical signals and to changes in its environment. Special mechanosensitive bone cells sense these signals and produce a number of proteins that lead to bone remodeling and strengthening for optimum mechanical performance.
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